2024
Lewis K, La Selva R, Maldonado E, Ouafa N, Canedo EC, Totten S, Sabourin V, Hebert S, Ciccolini E, Lehuede C, Annis M, Choiniere L, Russo M, Avizonis D, St-Pierre J, Kleinman CL, Siegel P, Ursini-Siegel J p66ShcA promotes malignant breast cancer phenotypes alleviating energetic and oxidative stress Redox Biology, 2023
2023
Sharma S, Kajjo S, Harra Z, Hasaj B, Delisle V, Ray D, Gutierrez RL, Carrier I, Kleinman CL, Morris Q, Hughes TR, McInnes R, Fabian MR Uncovering a mammalian neural-specific poly(A) binding protein with unique properties Genes & Development, 2023
Litzler LC, Zahn A, Sprumont A, Dionne KL, Ferreira SR, Slattery M, Methot SP, Patenaude AM, Hébert S, Kabir N, Subramani PG, Jung S, Richard S, Kleinman CL, Di Noia JM Protein Arginine Methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice Journal of Experimental Medicine, 2023
Desjardins-Lecavalier N, Annis MG, Nowakowski A, Kiepas A, Binan L, Roy J, Modica G, Hébert S, Kleinman CL, Siegel PM*, Costantino S* Migration speed of captured breast cancer subpopulations correlates with metastatic fitness Journal of Cell Science, 2023
McNicholas M^, De Cola A^, Bashardanesh Z, Foss A, Lloyd C, Hebert S,Faury D, Andrade AF, Jabado N*, Kleinman CL*, Pathania M* A compendium of syngeneic, transplantable pediatric high-grade glioma models reveals subtype-specific therapeutic vulnerabilities Cancer Discovery, 2023
Khazaei S^, Chen CCL^, Kabir N, Azarafshar P, Andrade AF, Morcos SM, Alves França J, Lopes M, Lund PJ, Adnani L, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ, Bryant L, Hébert S, Tong B, Sihota TS, Faury D, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam B, Cavalieri Gomes C, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K, Coca-nougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI, Kleinman CL*, Garzia L*, Jabado N* Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration Cell, 2023
Makhani K, Chiavatti C, Silva FN, Lemaire M, Bolt AM, De Jay N, Giles B, Zengin N, Kleinman CL, Mann KK Arsenic Causes Distinct Gene Expression Changes in Macrophages Polarized in vitro with either interferon-γ (IFN-γ) or interleukin-4 (IL-4) Toxicological Sciences, 2023
2022
Jessa S^, Mohammadnia A^, Harutyunyan AS^, Hulswit M, Varadharjan S, Lakkis H, Kabir N, Bashardanesh Z, Hébert S, Faury D, Vladoiu MC, Worme S, Coutelier M, Krug B, Faria Andrade A, Pathania M, Bajic A, Weil AG, Ellezam B, Atkinson J, Dudley R, Farmer JP, Perreault S, Garcia BA, Larouche V, Blanchette M, Garzia L, Bhaduri A, Bandopadhayay P, Taylor MD, Mack SC, Jabado N*, Kleinman CL* K27M in canonical and noncanonical H3 variants targets distinct oligodendroglial precursor-like cells in brain midline gliomas Nature Genetics, 2022
Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia JJ, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang EY, Kumar SA, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Bérubé P, Wang YC, Pfister SM, Kim SK, Delattre O, Bourdeaut F, Doz F, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks P, Fèvre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng HK, Poon WS, Pollack IF, López-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Iolascon A, Ferrucci V, de Antonellis P, Zollo M, Cinalli G, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, Chico F, Eguía P, Pérezpeña M, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Reimand J, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Golden JA, Ellison DW, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE, Suzuki H, Millen KJ, Taylor MD Failure of differentiation of the human split rhombic lip subventricular zone constitutes Group 4 Medulloblastoma Nature, 2022
Zwaig M, Baguette A, Hu B, Johnston M, Lakkis H, Nakada EM, Faury D, Juretic N, Ellezam B, Weil AG, Karamchandani J, Majewski J, Blanchette M, Taylor MD, Gallo M, Kleinman CL, Jabado N, Ragoussis J Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and inte-gration of multi-omic data BMC Cancer, 2022
Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Cat-terall R, McCaffrey L, Deblois G, Kleinman CL, Park M, Basik M, Witcher M 3D Chromatin Remodeling Potentiates Transcriptional Programs Driving Cell Invasion PNAS, 2022
Tsai JW, Cejas P, Wang DK, Patel S, Wu DW, Arounleut P, Wei X, Zhou N, Syamala S, Dubois FPB, Crane A, Pelton K, Vogelzang J, Sousa C, Baguette A, Chen X, Condurat AL, Dixon-Clarke SE, Zhou KN, Lu SD, Gonzalez EM, Chacon MS, Digiacomo JJ, Kumbhani R, Novikov D, Hunter JY, Tsoli M, Ziegler DS, Dirksen U, Jager N, Balasubramanian GN, Kramm CM, Nathrath M, Bielack S, Baker SJ, Zhang J, McFarland JM, Getz G, Aguet F, Jabado N, Witt O, Pfister SM, Ligon KL, Kleinman CL, Long H, Jones DTW*, Bandopadhayay P*, Phoenix TN* FOXR2 is a pan-cancer oncogene that is epigenetically regulated and activates ETS transcriptional circuits Cancer Research, 2022
Dubois FPB, Shapira O, Greenwald NF, Zack T, Wala J, Tsai JW, Crane A, Baguette A, Hadjadj D, Harutyunyan AS, Kumar KH, Blattner-Johnson M, Vogelzang J, Sousa C, Kang KS, Sinai C, Wang DK, Khadka P, Lewis K, Nguyen L, Malkin H, Ho P, O’Rourke R, Zhang S, Gold S, Deng D, Serrano J, Snuderl M, Jones C, Wright KD, Chi SN, Grill J, Kleinman CL, Goumnerova LC, Jabado N, Jones DTW, Kieran MW, Ligon KL*, Beroukhim R*, Bandopadhayay P* Structural variants shape driver combinations and outcomes in pediatric high-grade glioma Nature Cancer, 2022
Golbourn BJ^, Halbert ME^, Halligan K, Varadharajan S, Krug B, Mbah NE, Kabir N, Stanton AJ, Locke AL, Casillo SM, Zhao Y, Sanders LM, Cheney A, Mullett SJ, Chen A, Wassell M, Andren A, Perez J, Jane EP, Premkumar DRD, Koncar RF, Mirhadi S, McCarl LH, Chang YF, Wu YL, Gatesman TA, Cruz AF, Zapotocky M, Hu B, Kohanbash G, Wang X, Vartanian A, Moran MF, Lieberman F, Amankulor NM, Wendell SG, Vaske OM, Panigrahy A, Felker J, Bertrand KC, Kleinman CL, Rich JN, Friendlander RM, Broniscer A, Lyssiotis C, Jabado N, Pollack IF, Mack SC*, Agnihotri S* Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome Nature Cancer, 2022
2021
Tessier Cloutier B, Kleinman CL, Foulkes WD SWI/SNF undifferentiated malignancies: where to draw the line? Journal of Pathology, 2021
Chaouch A, Berlandi J, Frey F, Chen CCL, Badini S, Marchione DM, Garcia BA, Harutyunyan AS, Krug B, Chen H, Majewski J, Hébert S, Jeibmann A, Kleinman CL, Hasselblatt M, Lasko PF, Shirinian M, Jabado N Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks Molecular Cell, 2021
Sweha SR, Chung C, Natarajan SK, Panwalkar P, Pun M, Ghali A, Bayliss J, Pratt D, Shankar A, Ravikumar V, Rao A, Cieslik M, Wilder-Romans K, Scott AJ, Wahl DR, Jessa S, Kleinman CL, Jabado N, Mackay A, Jones C, Martinez D, Santi M, Judkins AR, Yadav VN, Qin T, Phoenix TN, Koschmann CJ, Baker SJ, Chinnaiyan AM, Venneti S Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas Science Translational Medicine, 2021
Kuzmin E, Monlong J, Martinez C, Kuasne H, Kleinman CL, Ragoussis J, Bourque G, Park M Inferring Copy Number from Triple-Negative Breast Cancer Patient Derived Xenograft scRNAseq Data Using scCNA Methods in Molecular Biology, 2021
Wei X, Jessa S, Kleinman CL, Phoenix TN Mapping Angiopoietin1 expression in the developing and adult brain Developmental Neuroscience, 2021
Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, De Jay N, Spinelli C, Chennakrishnaiah S, Choi D, Adnani L, Zeinieh M, Jabado N, Kleinman CL, Witcher M, Riazalhosseini Y, Key NS, Schiff D, Grover SP, Mackman N, Couturier CP, Petrecca K, Suvà ML, Patel A, Tirosh I, Najafabadi H, Rak J Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles Blood Advances, 2021
Gambaro K^, Marques M^, McNamara S, Couetoux du Tertre M, Diaz Z, Hoffert C, Srivastava A, Hébert S, Samson B, Lespérance B, Ko YJ, Dalfen R, St-Hilaire E, Sideris L, Couture F, Burkes R, Harb M, Camlioglu E, Gologan A, Pelsser V, Constantin A, Greenwood CMT, Tejpar S, Kavan P, Kleinman CL*, Batist G* Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer Clinical and Translational Medicine, 2021
Totten SP, Im YK, Najyb O, Cañedo EC, Nguyen A, Hébert S, Ahn R, La Selva R, Sabourin V, Ramírez CM, Savage P, Kuasne H, Avizonis D, Martínez NS, Chabot C, Aguilar-Mahecha A, Goulet M, Dankner M, Witcher M, Petrecca K, Basik M, Pollak M, Topisirovic I, Lin R, Siegel PM, Kleinman CL, Park M, St-Pierre J and Ursini-Siegel J. STAT1-induced inflammation potentiates oxidative stress and sensitizes breast cancers to mitochondrial complex I inhibitors. Nature Communications, 2021
Lazar V, Magidi S, Girard N, Savignoni A, Martini JF, Massimini G, Bresson C, Berger R, Onn A, Raynaud J, Wunder F, Berindan-Neagoe I, Sekacheva M, Braña I, Tabernero J, Felip E, Porgador A, Kleinman CL, Batist G, Solomon B, Tsimberidou AM, Soria JC, Rubin E, Kurzrock R, Schilsky RL. Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival NPJ Precision Oncology, 2021
Arabzade A^, Zhao Y^, Varadharajan S^, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton ACJ, San Chan Y, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac S, Ngo M, Wang PR, De Leon LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chuntagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC. C11orf95-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. Cancer Discovery, 2021
Fujita R, Jamet S, Lean G, Cheng HCM, Hébert S, Kleinman CL and Crist C. Satellite cell expansion is mediated by P-eIF2a dependent Tacc3 translation. Development, 2021
Gambaro K^, Marques M^, McNamara S, Couetoux du Tertre M, Diaz Z, Hoffert C, Srivastava A, Hébert S, Samson B, Lespérance B, Ko YJ, Dalfen R, St-Hilaire E, Sideris L, Couture F, Burkes R, Harb M, Camlioglu E, Gologan A, Pelsser V, Constantin A, Greenwood C, Tejpar S, Kavan P, Kleinman CL*, Batist G*. Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer. Clinical and Translational Medicine, 2021
Lazar V, Magidi S, Girard N, Savignoni A, Martini JF, Massimini G, Bresson C, Berger R, Onn A, Raynaud J, Wunder F, Berindan-Neagoe I, Sekacheva M, Braña I, Tabernero J, Felip E, Porgador A, Kleinman CL, Batist G, Tsimberidou AM, Soria JC, Kurzrock R, Rubin E, Schilsky RL. Digital Display Precision Predictor: the prototype of a global novel biomarker model to guide treatments with targeted therapy and predict progression-free survival. NPJ Precision Oncology, 2021
Khan A, Gamble LD, Upton DH, Ung C, Yu DMT, Ehteda A, Pandher R, Mayoh C, Hébert S, Jabado N, Kleinman CL, Burns MR, Norris MD, Haber M, Tsoli M, Ziegler DS. Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas. Nature Communications, 2021
Tawil N, Bassawon R, Meehan B, Nehme A, Montermini L, Gayden T, De Jay N, Spinelli C, Chennakrishnaiah S, Choi D, Adnani D, Zeinieh M, Jabado N, Kleinman CL , Witcher M, Riazalhosseini Y, Key NS, Schiff D, Grover SP, Mackman N, Couturier CP, Petrecca K, Suvà ML, Patel A, Tirosh I, Najafabadi H, Rak J. Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles. Blood advances, 2021
2020
Chen CCL^, Deshmukh S^, Jessa S^, Hadjadj D^, Lisi V, Andrade AF, Faury D, Jawhar W, Dali R, Suzuki H, Pathania M, Deli A, Dubois F, Woodward E, Hébert S, Coutelier M, Karamchandani J, Albrecht S, Brandner S, De Jay N, Gayden T, Bajic A, Harutyunyan AS, Marchione DM, Mikael LG, Juretic N, Zeinieh M, Russo C, Maestro N, Bassenden AV, Hauser P, Virga J, Bognar L, Klekner A, Zapotocky M, Vicha A, Krskova L, Vanova K, Zamecnik J, Sumerauer D, Ekert PG, Ziegler DS, Ellezam B, Filbin MG, Blanchette M, Hansford JR, Khuong-Quang DA, Berghuis AM, Weil AG, Garcia BA, Garzia L, Mack SC, Beroukhim R, Ligon KL, Taylor MD, Bandopadhayay P, Kramm C, Pfister SM, Korshunov A, Sturm D, Jones DTW, Salomoni P, Kleinman CL* and Jabado N*. Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis. Cell, 2020
Khazaei S^, De Jay N^, Deshmukh S^, Hendrikse LD^, Jawhar W, Chen CCL, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil E, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, Karamchandani J, Dickson BC, Turcotte R, Wunder JS, Thibault P, Lewis PW, Garcia BA, Mack SC, Taylor MD, Garzia L, Kleinman CL*, Jabado N*. H3.3 G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Cancer Discovery. 2020
Brothers WR, Hébert S, Kleinman CL, Fabian MR. A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. eLife, 2020
Brahimi F, Galan A, Jmaeff S, Barcelona PF, De Jay N, Dejgaard K, Young JC, Kleinman CL, Thomas DY, Saragovi HU. Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands. iScience, 2020
Lebel ME, Coutelier M, Galipeau M, Kleinman CL, Moon JJ, Melichar HJ. Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates. Nature Communications, 2020
Li L, Maire CL, Bilenky M, Carles A, Heravi-Moussavi A, Hong C, Tam A, Kamoh B, Cho S, Cheung D, Li I, Wong T, Nagarajan RP, Mungall AJ, Moore R, Wang T, Kleinman CL, Jabado N, Jones SJ, Marra MA, Ligon KL, Costello JF, Hirst M. Epigenomic programming in early fetal brain development. Epigenomics, 2020
2019
Jessa S, Blanchet-Cohen A, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, Mikael LG, Ellezam B, Richer M, Allaire A, Weil AG, Atkinson J, Farmer JP, Dudley RWR, Larouche V, Crevier L, Albrecht S, Filbin MG, Sartelet H, Lutz PE, Nagy C, Turecki G, Costantino S, Dirks PB, Murai KK, Bourque G, Ragoussis J, Garzia L, Taylor MD*, Jabado N*, Kleinman CL*.
Stalled developmental programs at the root of pediatric brain tumours. Nature Genetics 2019
Krug B*, De Jay N*, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen C, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, Lewis PW, Salomoni P, Lupien M, Arrowsmith C, Lasko PF, Garcia BA, Kleinman CL*,Jabado N*, Mack SC*.
Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas. Cancer Cell, 2019
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy SA, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner A, Jabado N, Stein L, Taylor MD.
Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature, 2019.
Sin-Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, Du Y, Lu M, Patel N, Torchia J, Popovski D, Fouladi M, Guilhamon P, Hansford JR, Leary S, Hoffman LM, Mulcahy Levy JM, Lassaletta A, Solano-Paez P, Rivas E, Reddy A, Gillespie GY, Gupta N, Van Meter TE, Nakamura H, Wong TT, Ra YS, Kim SK, Massimi L, Grundy RG, Fangusaro J, Johnston D, Chan J, Lafay-Cousin L, Hwang EI, Wang Y, Catchpoole D, Michaud J, Ellezam B, Ramanujachar R, Lindsay H, Taylor MD, Hawkins CE, Bouffet E, Jabado N, Singh SK, Kleinman CL, Barsyte-Lovejoy D, Li XN, Dirks PB, Lin CY, Mack SC, Rich JN, Huang A.
A C19MC-LIN28A-MYCN oncogenic circuit driven by hijacked super-enhancers is a distinct therapeutic vulnerability in ETMRs: a lethal brain tumor.
Cancer Cell, 2019
Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire MJ, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier MS, Coulombe B, Brais B. The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA Polymerase III biogenesis. Molecular Brain. 2019;12(1):59
Boileau M, Shirinian M, Gayden T, Harutyunyan AS, Chen CCL, Mikael LG, Duncan HM, Neumann AL, Arreba-Tutusaus P, De Jay N, Zeinieh M, Rossokhata K, Zhang Y, Nikbakht H, Mouawad C, Massoud R, Frey F, Nasr R, El Cheikh J, El Sabban M, Kleinman CL, Mahfouz R, Minden MD, Jabado N, Bazarbachi A, Eppert K.
Mutated H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.
Nature Communications, 2019
Choquet K, Forget D, Meloche E, Dicaire MJ, Bernard G, Vanderver A, Shiffmann R, Fabian MR, Teichmann M, Coulombe B, Brais B, Kleinman CL*. Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200. Journal of Biological Chemistry, 2019
Wu T, Bolt AM, Chou H, Plourde D, De Jay N, Guilbert C, Young YK, Kleinman CL, Mann KK.
Tungsten Blocks Murine B Lymphocyte Differentiation and Proliferation Through Downregulation of IL-7 Receptor/Pax5 Signaling.
Toxicological Sciences, 2019
Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M.
SWI/SNF-compromised cancers are susceptible to bromodomain inhibitors. Cancer Research, 2019
Berlandi J, Chaouch A, De Jay N, Tegeder I, Thiel K, Shirinian M, Kleinman CL, Jeibmann A, Lasko P, Jabado N, Hasselblatt M.
Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila Melanogaster.
Neuro-oncology, 2019
Harutyunyan A, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J.
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Nature Communications, 2019
Litzler LC, Zahn A, Meli A, Hébert S, Patenaude AM, Methot SP, Sprumont A, Bois T, Kitamura D, Costantino S, King IL, Kleinman CL, Richard S, Di Noia JM.
PRMT5 is essential for B cell development and germinal center dynamics. Nature Communications, 2019
2018
Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Henriques Castro W, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET, Bassenden AV, Berghuis AM, Majewski J, Nelson MT, Gomez RS, Jabado N.
TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nature Communications, 2018
Vairy S, Jouan L, Bilodeau M, Dormoy-Raclet V, Gendron P, Couture F, Léveillé F, Tihy F, Lemyre E, Bouron-Dal Soglio D, Jabado N, Kleinman CL, Marzouki M, Cellot S.
Novel PDE10A-BRAF fusion with concomitant NF1 mutation identified in an undifferentiated sarcoma of infancy with sustained response to Trametinib. JCO Precision Oncology, 2018
Calabretta S, Vogel G, Yu Z, Choquet K, Darbelli L, Nicholson TB, Kleinman CL, Richard S.
Loss of PRMT5 promotes PDGFRα degradation during oligodendrocyte differentiation and myelination. Developmental Cell, 2018
Jessa, S, Kleinman CL.
chromswitch: a flexible method to detect chromatin state switches.
Bioinformatics, 2018
Ha JR, Ahn R, Smith HW, Sabourin V, Hébert S, Cepeda Cañedo E, Im YK, Kleinman CL, Muller WJ, Ursini-Siegel J. Integration of distinct ShcA signaling complexes promotes breast tumor growth and tyrosine kinase inhibitor resistance. Molecular Cancer Research, 2018
2017
Pathania M, De Jay N, Maestro N, Harutyunyan AS, Nitarska J, Pahlavan P, Henderson S, Mikael LG, Richard-Londt A, Zhang Y, Costa JR, Hébert S, Khazaei S, Ibrahim NS, Herrero J, Riccio A, Albrecht S, Ketteler R, Brandner S, Kleinman CL, Jabado N*, Salomoni P*. H3.3K27M cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas. Cancer Cell. 2017
Savage P, Blanchet-Cohen A, Revil T, Badescu D, Saleh SMI, Wang YC, Zuo D, Liu L, Bertos NR, Munoz-Ramos V, Basik M, Petrecca K, Asselah J, Meterissian S, Guiot MC, Omeroglu A, Kleinman CL, Park M, Ragoussis J. A targetable EGFR-dependent tumor-initiating program in breast cancer. Cell Reports, 2017
Kleinman CL*, Sycz G, Bonomi HR, Rodríguez RM, Zorreguieta A, Sieira R*. ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network. Nucleic Acids Research, 2017
Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA. A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. EMBO Reports, 2017
Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J. The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression. Nature Communications, 2017
Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathologica Communications, 2017
Darbelli L, Choquet K, Richard S*, Kleinman CL*. Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing. Scientific Reports, 2017
Li N, Hébert S, Song J, Kleinman CL, Richard S. Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets. Oncotarget, 2017
Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B. Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Molecular Brain, 2017
Forest M, Iturria-Medina Y, Goldman JS, Kleinman CL, Lovato A, Klein KO, Evans A, Ciampi A, Labbe A, Greenwood CMT. Gene networks show associations with seed region connectivity. Human Brain Mapping, 2017
2016 & before
Binan L, Mazzaferri J, Choquet K, Lorenzo LE, Wang YC, Affar el B, De Koninck Y, Ragoussis J, Kleinman CL*, Costantino, S*. Live single-cell laser tag. Nature Communications, 2016
Nichol JN, Galbraith MD, Kleinman CL, Espinosa JM and Miller WH. NPM and BRG1 mediate transcriptional resistance to retinoic acid in acute promyelocytic leukemia. Cell Reports, 2016
Costantino C, Kleinman CL, Painting cells with light. The Biochemist, 2016
Bourguinat C, Lee AC, Lizundia R, Blagburn BL, Liotta JL, Kraus MS, Keller K, Epe C, Letourneau L, Kleinman CL, Paterson T, Gomez EC, Montoya-Alonso JA, Smith H, Bhan A, Peregrine AS, Carmichael J, Drake J, Schenker R, Kaminsky R, Bowman DD, Geary TG, Prichard RK. Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance. Veterinary Parasitology, 2015
Kleinman CL et al. Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumour ETMR. Nature Genetics, 2014
Kleinman CL, Doria M, Orecchini E, Giuliani E, Galardi S, De Jay N, Michienzi A. HIV-1 infection causes a down-regulation of genes involved in ribosome biogenesis. PLoS One, 2014
Beaulieu YB, Kleinman CL, Landry-Voyer AM, Majewski J, Bachand F. Polyadenylation-dependent control of long noncoding RNA expression by the poly(A) binding protein nuclear 1. PLoS Genetics, 2012
Kleinman CL, Adoue V and Majewski J. RNA editing of protein sequences: a rare event in human transcriptomes. RNA, 2012
Kleinman CL, Majewski J. Comment on "Widespread RNA and DNA sequence differences in the human transcriptome". Science, 2012
This article has been highlighted in Nature
Lalonde E, Ha KC, Wang Z, Bemmo A, Kleinman CL, Kwan T, Pastinen T, Majewski J. RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression. Genome Research, 2011
Kleinman CL, Rodrigue N, Lartillot N and Philippe H. Statistical potentials for improved structurally constrained evolutionary models. Molecular Biology and Evolution, 2010
Bonnard C, Kleinman CL, Rodrigue N and Lartillot N. Fast optimization of statistical potentials for structurally constrained phylogenetic models. BMC Evolutionary Biology, 2009
Rodrigue N, Kleinman CL, Phillipe H and Lartillot N. Computational methods for evaluating phylogenetic models of coding sequence evolution with dependence between codons. Molecular Biology and Evolution, 2009
Santos J, Marino-Buslje C, Kleinman CL, Ermacora MR and Delfino JM. Consolidation of the thioredoxin fold by peptide recognition: interaction between E. coli thioredoxin fragments 1-93 and 94-108. Biochemistry, 2007
Kleinman CL, Rodrigue N, Bonnard C, Philippe H and Lartillot N. A maximum likelihood framework for protein design. BMC Bioinformatics, 2006